反应详情

A mixture of 10.0 g of 2-[4-(4-acetylphenoxy]-butyl]-1H-isoindole-1,3(2H)-dione (Example 42) 10.0 g of tris(formamido)methane, and 20 ml of formamide are combined and the mixture stirred and heated at 160°-165° C. for 8 hours. After dilution with 100 ml of water, the mixture is rendered basic with 10N NaOH, the precipitate collected, washed with water, and air dried. Recrystallization from ethanol gives the pure compound, m.p. 100°-102° C.; yield, 5.0 g.

1. temperatureheated at 160°-165° C. for 8 hours
2. customthe precipitate collected
3. washwashed with water, and air
4. customdried
5. customRecrystallization from ethanol
6. customgives the pure compound, m.p. 100°-102° C.
7. customyield