Hydrochloric Acid → 8-Amino-octanoic acid methyl-butyl-amide

HRID 1417420노트

반응식

HRID 1417420 반응식
[CH3:1][N:2]([CH2:20][CH2:21][CH2:22][CH3:23])[C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11]C(OC(C)(C)C)=O.Cl>O1CCOCC1>[CH3:1][N:2]([CH2:20][CH2:21][CH2:22][CH3:23])[C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 537219698-(t-Butoxycarbonyl)amino-octanoic acid methyl-butyl-amide

생성물 1

HCID 541906878-Amino-octanoic acid methyl-butyl-amide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Combine 8-(t-butoxycarbonyl)amino-octanoic acid methyl-butyl-amide and 4M hydrochloric acid in dioxane (10 mL). After 1 hour, the reaction mixture is evaporated to a residue. Partition the residue between toluene and 1M sodium hydroxide solution. Extract the aqueous layer with toluene. Combine the organic layers, dry over MgSO4, and filter to give the title compound as a toluene solution. Evaporate in vacuo to give the title compound.

후처리

  1. customthe reaction mixture is evaporated to a residue
  2. customPartition the residue between toluene and 1M sodium hydroxide solution
  3. extractionExtract the aqueous layer with toluene
  4. dry with materialdry over MgSO4
  5. filtrationfilter

출처 및 근거

ORD 기록
ord-1fb774483c154405bca8f0fa6a4001ad
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877202

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