Hexahydro-1,4-diazepine → (S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzamide methanesulfonate

HRID 1417860

반응식

HRID 1417860 반응식
[CH:1]1([CH2:11][CH2:12]O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][O:2]1.[N:14]1([C:21]2[CH:29]=[CH:28][C:24]([C:25]([NH2:27])=[O:26])=[CH:23][CH:22]=2)[CH2:20][CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.N1(C2C=C[C:39]([S:42](N)(=[O:44])=[O:43])=CC=2)CCNCC1.FC1C=CC(C(N)=[O:52])=CC=1.CNS(C1C=CC(F)=CC=1)(=O)=O.CNS(C1C=CC(N2CCN(CC[C@H]3C4C(=CC=CC=4)CCO3)CC2)=CC=1)(=O)=O.N1CCCNCC1.C[C@H]1CNC[C@@H](C)N1>>[CH3:39][S:42]([OH:44])(=[O:52])=[O:43].[C@H:1]1([CH2:11][CH2:12][N:17]2[CH2:18][CH2:19][CH2:20][N:14]([C:21]3[CH:22]=[CH:23][C:24]([C:25]([NH2:27])=[O:26])=[CH:28][CH:29]=3)[CH2:15][CH2:16]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][O:2]1

참가 물질

8

반응물 7

HCID 68163Hexahydro-1,4-diazepineHCID 715724-FluorobenzamideHCID 9018974-(Piperazin-1-yl)benzene-1-sulfonamideHCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 14141298(-)-2-(Isochroman-1-yl)ethanolHCID 284109314-(Homopiperazin-1-yl)benzamideHCID 86753846N-Methyl-(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide N-Methyl-4-fluorobenzenesulfonamide

생성물 1

HCID 86753847(S)-(-)-4-[4-[2-(Isochroman-1-yl)ethyl]homopiperazin-1-yl]benzamide methanesulfonate

실험 절차

Following the general procedure for EXAMPLE 49 and making non-critical variations (-)-2-(isochroman-1-yl)ethanol (LXXIX, 0.394 g) and 4-(homopiperazin-1-yl)benzamide (IV; 0.601 g prepared by the method of EXAMPLE 47, Step 1 from 4-fluorobenzamide, III, and homopiperazine, II) are combined to give the title compound, mp 163.75°-165°; MS (m/z) 379; [α]D -41° (c, 0.975, DMF); IR(mineral oil) 1609, 1043, 1662, 1167 and 1216 cm-1.

출처 및 근거

ORD 기록
ord-e68cdfcc45d54cc0aa5e138216c234c0
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05877317

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