Glycine → Glycine, N-dodecyl-

HRID 1417866

반응식

HRID 1417866 반응식
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].C(N(CC)CC)C.Br[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>CC(O)C.O>[CH2:25]([NH:1][CH2:2][C:3]([OH:5])=[O:4])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH3:14]

참가 물질

6

반응물 3

HCID 750GlycineHCID 8471TriethylamineHCID 89191-Bromododecane

생성물 1

HCID 16771Glycine, N-dodecyl-수율 26.3%

시약·촉매·용매 2

HCID 962Water용매HCID 3776Isopropanol용매

실험 절차

Glycine was dissolved in a 2:1 mixture by volume of IPA and water. Triethylamine and 1-bromododecane were added to the solution successively and the mixture was kept stirring for more than 7 days. After the solvent was removed, THF was added to the remaining material. Triethylamine hydrobromide was removed by filtration and the filtrate was concentrated. N-n-dodecylglycine was obtained from the concentrated solution by separation and purification by column chromatography with the yield of 26.3%.

후처리

  1. customAfter the solvent was removed
  2. additionTHF was added to the remaining material
  3. customTriethylamine hydrobromide was removed by filtration
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-a94051af64e743c9a743f87c0b107717
출처 데이터셋
uspto-grants-1999_03
특허 번호
USRE036138

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