Hydrochloric Acid → N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide hydrochloride

HRID 1418189노트

반응식

HRID 1418189 반응식
[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][C:7]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:5])([CH3:4])[CH3:3]>O1CCOCC1.C(OCC)C>[ClH:1].[C:2]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][NH2:13])=[CH:8][C:7]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:3])([CH3:4])[CH3:5]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 19348478HCID 19348478, 화합물

생성물 1

HCID 19348562N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide hydrochloride

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

실험 절차

A 4N solution of hydrogen chloride in dioxane was added to a solution of N-[2-t-butyl-5-(aminomethyl)phenyl]-3-(2,4-dimethoxyphenyl)octanamide (prepared as described in Preparation 26A) in diethyl ether, and the precipitate which separated out was collected by filtration and washed with hexane to give the desired hydrochloride, melting at 102°-106° C.

후처리

  1. customthe precipitate which separated out
  2. filtrationwas collected by filtration
  3. washwashed with hexane

출처 및 근거

ORD 기록
ord-bf3bf3f32ca040d7a2142ed252ab3f47
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05880147

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