Hydrochloric Acid → 3-Nitro-5-vinylbenzoic acid methyl ester
반응식
[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[C:8]([CH:10]=[CH:11][Si](C)(C)C)[CH:7]=[C:6]([N+:16]([O-:18])=[O:17])[CH:5]=1.Cl>C(#N)C>[CH3:1][O:2][C:3](=[O:19])[C:4]1[CH:9]=[C:8]([CH:10]=[CH2:11])[CH:7]=[C:6]([N+:16]([O-:18])=[O:17])[CH:5]=1참가 물질
4
실험 절차
3-Nitro-5-(2-trimethylsilylvinyl)benzoic acid methyl ester (2.44 g, 8.71 mmol) was dissolved in acetonitrile (150 ml), the solution was heated to reflux temperature and HCl gas was bubbled through the solution until the starting material had disappeared according to HPLC analysis. The solution was allowed to cool and the solvent was removed by evaporation. The residue was >95% pure according to HPLC and was used without further purification. Yield: 2.02 g (89%).
후처리
- temperaturethe solution was heated
- customwas bubbled through the solution until the starting material
- temperatureto cool
- customthe solvent was removed by evaporation
- customwas used without further purification
출처 및 근거
- ORD 기록
- ord-5a19b2cfdf1f4a75a6b2a1695005b892
- 출처 데이터셋
- uspto-grants-1999_03
- 특허 번호
- US05882628
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