Water → 2-Fluoro-5-methoxybenzoic acid

HRID 1418537

반응식

HRID 1418537 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH3:10].[Mn]([O-])(=O)(=O)=[O:12].[K+].[OH2:17]>N1C=CC=CC=1>[F:1][C:2]1[C:3]([C:10]([OH:12])=[O:17])=[CH:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 1375464-Fluoro-3-methylanisoleHCID 516875Potassium Permanganate

생성물 1

HCID 27745432-Fluoro-5-methoxybenzoic acid

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

4-Fluoro-3-methylanisol (1.0 g, 7.1 mmol) was dissolved in a mixture of pyridine (16 mL) and water (32 mL). Potassium permanganate (3.4 g, 21 mmol) was added and the reaction mixture was refluxed for 3 h and then left at room temperature over night. After filtration and extraction with CH2Cl2 the aqueous phase was acidified with HCl precipitating the product (440 mg).

후처리

  1. temperaturethe reaction mixture was refluxed for 3 h
  2. waitleft at room temperature over night
  3. filtrationAfter filtration and extraction with CH2Cl2 the aqueous phase

출처 및 근거

ORD 기록
ord-380c8240f3b24bb39227e29db61c8684
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05883129

연결된 노트

불러오는 중…