Hydrochloric Acid → Ethyl-3-iodomethyl-4-iodobutyrate

반응식

[I:1][CH2:2][CH:3]([CH2:8][I:9])[CH2:4][C:5]([OH:7])=[O:6].Cl.[CH2:11](O)[CH3:12]>>[CH2:11]([O:6][C:5](=[O:7])[CH2:4][CH:3]([CH2:8][I:9])[CH2:2][I:1])[CH3:12]

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 219325543-Iodomethyl-4-iodobutyric acid

생성물 1

HCID 21932537Ethyl-3-iodomethyl-4-iodobutyrate

실험 절차

A solution of 2.831 g (8 mmole) 3-iodomethyl-4-iodobutyric acid in 80 mL ethanol is saturated with HCl gas at 0° C. After stirring the solution at room temperature for two days, the solvent is removed under vacuum, and the residue is dissolved in dichloromethane. The dichloromethane layer is washed with 10% aqueous sodium bicarbonate (3×100 mL), water (1×100 mL) and brine. The separated dichloromethane layer is dried over with magnesium sulfate, filtered and evaporated to give ethyl-3-iodomethyl-4-iodobutyrate.

후처리

customthe solvent is removed under vacuum
dissolutionthe residue is dissolved in dichloromethane
washThe dichloromethane layer is washed with 10% aqueous sodium bicarbonate (3×100 mL), water (1×100 mL) and brine
dry with materialThe separated dichloromethane layer is dried over with magnesium sulfate
filtrationfiltered
customevaporated

출처 및 근거

ORD 기록: ord-7d54368ba8564b68aca0a24353d69fbb
출처 데이터셋: uspto-grants-1999_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05886143

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