Hydrochloric Acid → N-[(4-Phenylpiperidin-4-yl)methyl]methanesulfonamide Hydrochloride
반응식
[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][C:12]([CH2:21][NH:22][S:23]([CH3:26])(=[O:25])=[O:24])([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)=O)(C)(C)C>CO>[ClH:1].[C:15]1([C:12]2([CH2:21][NH:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1참가 물질
4
실험 절차
Methanolic hydrogen chloride (4M, 40 mL) was added to a stirred, cooled (0° C.) suspension of N-[(1-t-butoxycarbonyl-4-phenylpiperidin-4-yl)methyl]methanesulfonamide (5.65 g, 15.4 mmol) in methanol (20 mL) and the mixture was stirred at room temperature for 20 h. The solvent was evaporated under reduced pressure to give the title compound as a tan solid (4.66 g, 100%), δH (250 MHz, d6 -DMSO) 9.05 (1H, br s), 8.86 (1H, br s), 7.41-7.26 (5H, m), 6.95 (1H, t, J 6.9 Hz), 3.18 (2H, m), 3.05 (2H, d, J 6.9 Hz), 2.70 (2H, m), 2.64 (3H, s), 2.26 (2H, m), and 2.02 (2H, m).