Trifluoroacetic acid methylene chloride → HCID 67556317, 화합물

HRID 1419565

반응식

HRID 1419565 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].ClCCl>>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[C:18]1([C:11]2([C:14]([O:16][CH3:17])=[O:15])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

참가 물질

3

반응물 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 538083811-Boc-4-phenyl-4-piperidinedicarboxylic acid methyl ester

생성물 1

HCID 67556317HCID 67556317, 화합물

실험 절차

Methyl 1-t-butoxycarbonyl-4-phenylpiperidine-4-carboxylate (5.0 g) was dissolved in trifluoroacetic acid-dichloromethane (10%, 100 mL) and the mixture was stirred at room temperature for 6 h. The solvent was evaporated under reduced pressure to give the title compound as a yellow gum (5.2 g), δH (CDCl3) 2.11-2.20 (2H, m), 2.64-2.68 (2H, m), 3.03-3.13 (2H, m), 3.38-3.44 (2H, m), 3.63 (3H, s), 7.18-7.33 (5H, m), and 7.98 (1H, br s).

후처리

  1. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-a25aff33540e4836a46c3441f20036ee
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05885999

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