Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid methylene chloride → Methyl 4-Phenylpiperidine-4-carboxylate Trifluoroacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 반응물 | 1-Boc-4-phenyl-4-piperidinedicarboxylic acid methyl ester | HCID 53808381 | — |
| 생성물 | Methyl 4-Phenylpiperidine-4-carboxylate Trifluoroacetate | HCID 67556317 | — |
반응 단계
Methyl 1-t-butoxycarbonyl-4-phenylpiperidine-4-carboxylate (5.0 g) was dissolved in trifluoroacetic acid-dichloromethane (10%, 100 mL) and the mixture was stirred at room temperature for 6 h. The solvent was evaporated under reduced pressure to give the title compound as a yellow gum (5.2 g), δH (CDCl3) 2.11-2.20 (2H, m), 2.64-2.68 (2H, m), 3.03-3.13 (2H, m), 3.38-3.44 (2H, m), 3.63 (3H, s), 7.18-7.33 (5H, m), and 7.98 (1H, br s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05885999 |
| 출처 데이터셋 | uspto-grants-1999_03 |
| ORD ID | ord-a25aff33540e4836a46c3441f20036ee |
| 출처 메모 | uspto-grants-1999_03 |