Water → (4-Methylpyridin-2-yl)acetonitrile

HRID 1419854노트

반응식

HRID 1419854 반응식
Cl[CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1.[C-:10]#[N:11].[K+].O>CS(C)=O>[C:10]([CH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][N:4]=1)#[N:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 9032Potassium CyanideHCID 126752612-(Chloromethyl)-4-methylpyridine

생성물 1

HCID 12812206(4-Methylpyridin-2-yl)acetonitrile수율 1,112.3%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

2-chloromethyl-4-methylpyridine (3.70 g, 2.17 mmol) was dissolved in dimethyl sulfoxide (9 ml) and herein potassium cyanide (1.70 g, 2.60 mmol) was added. After stirring for 17 hours at room temperature, water was added and it was extracted twice with diethyl ether. The combined organic layers were dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to get crude product. The residue was separated and purified by column-chromatography over silica gel to obtain the desired product (3.19 g, yield=95%).

후처리

  1. extractionit was extracted twice with diethyl ether
  2. dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customto get crude product
  5. customThe residue was separated
  6. custompurified by column-chromatography over silica gel

출처 및 근거

ORD 기록
ord-7cb8e14c17ad495b86580b80c13e8021
출처 데이터셋
uspto-grants-1999_03
특허 번호
US05889027

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