Thionyl Chloride → 2-(2-Chloroethoxy)pyridine hydrochloride
반응식
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1>ClC(Cl)Cl>[ClH:3].[Cl:3][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1참가 물질
4
반응 조건
- 온도
- 5 °C
실험 절차
Thionyl chloride (0.55 ml, 7.55 mmol) was added to a solution of 2-(2-hydroxyethoxy)pyridine (700 mg, 5.04 mmol), (J. Org. Chem. 1977, 42, 1500), in trichloromethane (20 ml) at 5° C. The mixture was stirred for 1 hour at 5° C., allowed to warm to ambient temperature and stirred for a further 1 hour. The volatiles were removed by evaporation and by azeotroping with toluene to give 2-(2-chloroethoxy)pyridine hydrochloride (970 mg, 99%).
후처리
- temperatureto warm to ambient temperature
- stirringstirred for a further 1 hour
- customThe volatiles were removed by evaporation
- customby azeotroping with toluene
출처 및 근거
- ORD 기록
- ord-2279d846e59e45bfbdce5a7d4fe8902c
- 출처 데이터셋
- uspto-grants-2000_06
- 특허 번호
- US06071921
반응 노트
불러오는 중…