Ethyl Acetoacetate → Ethyl alpha-acetyl-4-methoxybenzenepropanoate

HRID 1421254노트

반응식

HRID 1421254 반응식
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[CH3:10][O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1.N12CCCN=C1CCCCC2>CC#N>[CH2:8]([O:7][C:1](=[O:6])[CH:2]([CH2:16][C:15]1[CH:18]=[CH:19][C:12]([O:11][CH3:10])=[CH:13][CH:14]=1)[C:3](=[O:4])[CH3:5])[CH3:9]

참가 물질

5

반응물 3

HCID 8868Ethyl AcetoacetateHCID 699934-Methyloxybenzyl chlorideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-ene

생성물 1

HCID 12248936Ethyl alpha-acetyl-4-methoxybenzenepropanoate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of ethyl acetoacetate and 4-methoxybenzyl chloride is stirred under an argon atmosphere with 1,8-diazabicyclo[5.4.0]undec-7-ene at room temperature in CH3CN. The mixture is partitioned between 3 N HCl and EtOAc. The organic extract is washed successively with H2O, aqueous NaHCO3, H2O and saturated aqueous NaCl and dried (Na2SO4). The solvent is removed in vacuo to afford the title compound.

후처리

  1. customThe mixture is partitioned between 3 N HCl and EtOAc
  2. extractionThe organic extract
  3. washis washed successively with H2O, aqueous NaHCO3, H2O and saturated aqueous NaCl
  4. dry with materialdried (Na2SO4)
  5. customThe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-2e56d6cfdea142a6a9c8557bf84d89fb
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06075037

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