Furan → 3-(4-Methoxyphenylsulfonyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid

HRID 1421520노트

반응식

HRID 1421520 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH:12]=[CH:13][C:14]([OH:16])=[O:15])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[O:17]1[CH:21]=[CH:20][CH:19]=[CH:18]1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH:12]2[CH:21]3[O:17][CH:18]([CH:19]=[CH:20]3)[CH:13]2[C:14]([OH:16])=[O:15])(=[O:11])=[O:10])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 8029FuranHCID 538137123-(4-Methoxyphenylsulfonyl)propenoic acid

생성물 1

HCID 187798633-(4-Methoxyphenylsulfonyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
55 °C

실험 절차

3-(4-Methoxyphenylsulfonyl)propenoic acid (200 mgs), excess furan (5.0 ml), and dry toluene (5.0 ml) were combined and warmed to 55° C. (at which time starting material went into solution) for overnight. The cooled reaction was concentrated in vacuo to a tan solid which was a mixture of starting material and product. The material was taken up in toluene (5 ml) and furan (10 ml) and heated to 69° C. overnight. The cooled reaction mixture was concentrated in vacuo to give 251 mgs of crude 3-(4-Methoxyphenylsulfonyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid as a dark tan solid.

후처리

  1. customThe cooled reaction
  2. concentrationwas concentrated in vacuo to a tan solid which
  3. additiona mixture of starting material and product
  4. temperaturefuran (10 ml) and heated to 69° C. overnight
  5. customThe cooled reaction mixture
  6. concentrationwas concentrated in vacuo

출처 및 근거

ORD 기록
ord-ebef189ef64f4363ad57cc24d98b5e7e
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06077864

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