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Tributylstannane → 5-chloro-5'-(1-trityl-1H-imidazol-4-ylmethyl)-[1,2']bipyridinyl-2-one

HRID 1421706
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HRID 1421706 반응식
C1(OC(=S)O[CH:10]([C:35]2[CH:36]=[CH:37][C:38]([N:41]3[CH:46]=[C:45]([Cl:47])[CH:44]=[CH:43][C:42]3=[O:48])=[N:39][CH:40]=2)[C:11]2[N:12]=[CH:13][N:14]([C:16]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:15]=2)C=CC=CC=1.C([SnH](CCCC)CCCC)CCC.CC(N=NC(C#N)(C)C)(C#N)C>C1C=CC=CC=1>[Cl:47][C:45]1[CH:44]=[CH:43][C:42](=[O:48])[N:41]([C:38]2[CH:37]=[CH:36][C:35]([CH2:10][C:11]3[N:12]=[CH:13][N:14]([C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)([C:29]4[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=4)[C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:15]=3)=[CH:40][N:39]=2)[CH:46]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 5948TributylstannaneHCID 6547AzobisisobutyronitrileHCID 53650920Thiocarbonic acid O-[(5-chloro-2-oxo-2H-[1,2']bipyridinyl-5'-yl)-(1-trityl-1H-imidazol-4-yl)-methyl] ester O-phenyl ester

생성물 1

HCID 702869365-chloro-5'-(1-trityl-1H-imidazol-4-ylmethyl)-[1,2']bipyridinyl-2-one

시약·촉매·용매 1

HCID 241Benzene
용매

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온도
80 °C

실험 절차

To a solution of the thiocarbonate from Step 4 (0.263 g, 0.386 mmol) in benzene (3 ml) at room temperature was added tributyl tin hydride (0.159 ml, 3.74 mmol) and AIBN (0.012 g, 0.50 mmol) and the mixture was heated at 80° C. for 3 hrs. The solvent was evaporated in vacuo. The residue was chromatographed (silica gel, MeOH: CH2Cl2 2:98 to 4:96 gradient elution) to afford the title compound.

후처리

  1. customThe solvent was evaporated in vacuo
  2. customThe residue was chromatographed
  3. wash(silica gel, MeOH: CH2Cl2 2:98 to 4:96 gradient elution)

출처 및 근거

ORD 기록
ord-aefe3634d68b40548515319928db9aac
출처 데이터셋
uspto-grants-2000_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06077853

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