Hydrazine hydrate (1:1) → 2-Naphthohydrazide

HRID 1421915

반응식

HRID 1421915 반응식
C([O:3][C:4]([C:6]1[CH:15]=[CH:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1)=O)C.O.[NH2:17][NH2:18]>C(O)C>[CH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:14]=[CH:15][C:6]=1[C:4]([NH:17][NH2:18])=[O:3]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 76363Ethyl 2-naphthoate

생성물 1

HCID 1234852-Naphthohydrazide수율 48.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2-naphthyl carboxylic acid ethyl ester (2.0 g, 9.99 mmol) in absolute ethanol (30 ml) was added hydrazine hydrate (4.85 ml, 99.9 mmol) and the reaction mixture was heated at reflux temperature for 72 h. The reaction mixture was cooled and the precipitate was filtered off, washed with 96% ethanol (2×10 ml) and diethyl ether (3×10 ml), dried in vacuo at 50° C. which afforded 0.9 g (48%) of naphthalene-2-carboxylic acid hydrazide as a solid.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureat reflux temperature for 72 h
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe precipitate was filtered off
  5. washwashed with 96% ethanol (2×10 ml) and diethyl ether (3×10 ml)
  6. customdried in vacuo at 50° C. which

출처 및 근거

ORD 기록
ord-8a6b1a4a528e4c76b289a13586b8a40e
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080770

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