Hydrochloric Acid → 4-Fluorobenzimidic acid ethyl ester hydrochloride

HRID 1422056노트

반응식

HRID 1422056 반응식
[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[ClH:10].[CH2:11]([OH:13])[CH3:12]>>[ClH:10].[F:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:13][CH2:11][CH3:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 145174-Fluorobenzonitrile

생성물 1

HCID 122821594-Fluorobenzimidic acid ethyl ester hydrochloride수율 92%

실험 절차

Into a solution of 4-fluorobenznitrile (50.9 g, 0.420 mol) in ethanol (500 mL) was blown hydrogen chloride to saturation under ice-cooling and the mixture was stirred at room temperature for 21 hours. The solvent was evaporated under reduced pressure and the obtained crystals were washed with ether and dried in vacuo to give ethyl 4-fluorobenzimidate hydrochloride as white crystals (78.8 g, 92%).

후처리

  1. temperaturecooling
  2. customThe solvent was evaporated under reduced pressure
  3. washthe obtained crystals were washed with ether
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-21e48446e8d948debcdc37e22b76d4f5
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080738

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