Sodium Hydroxide → 5-Bromoisoquinoline

HRID 1422163

반응식

HRID 1422163 반응식
N[C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.N([O-])=O.[Na+].[OH-].[Na+].[BrH:18].O>O>[Br:18][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2

참가 물질

6

반응물 4

HCID 14798Sodium HydroxideHCID 707665-AminoisoquinolineHCID 22326455Hydrobromide monohydrate2회HCID 23668193Sodium Nitrite

생성물 1

HCID 7364875-Bromoisoquinoline

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
75 °C

실험 절차

To a cold (0° C.) solution of HBr-H2O (48%) (10 ml) in water (30 ml) was added 5-aminoisoquinoline (5 g; 35 mmol) followed by sodium nitrite (2.4 g; 35 mmol) in water (20 ml). The mixture was added to a warm (75° C.) solution of cuprous bromide (5 g; 35 mmol) in HBr-H2O (48%) (50 ml) and stirred overnight at 75° C. The reaction mixture was cooled, basified to pH11 with NaOH (5 M) and steamed distilled to afford the title compound (1.4 g) as a colourless crystalline solid (mp 65° C.).

후처리

  1. additionThe mixture was added to
  2. temperatureThe reaction mixture was cooled
  3. distillationsteamed distilled

출처 및 근거

ORD 기록
ord-09106672b3774edca067e001e238bcb2
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080790

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