Sodium → N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-morpholinopyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide

HRID 1422204

반응식

HRID 1422204 반응식
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([NH:14][S:15]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][N:19]=2)(=[O:17])=[O:16])[C:3]=1[O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH3:35].[Na]>C(O)CO>[OH:27][CH2:28][CH2:29][O:34][C:2]1[N:7]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:5]=[C:4]([NH:14][S:15]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][N:19]=2)(=[O:17])=[O:16])[C:3]=1[O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH3:35]

참가 물질

4

반응물 2

HCID 5360545SodiumHCID 227294065-Isopropyl-pyridine-2-sulfonic acid 6-chloro-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl-amide

생성물 1

HCID 22377859N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-morpholinopyrimidin-4-yl)-5-isopropylpyridine-2-sulfonamide

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

실험 절차

reacting the product of step d) with sodium in ethylene glycol to form 5-isopropyl-pyridine-2-sulfonic acid 6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yl-amide, and

출처 및 근거

ORD 기록
ord-64696ff521e34823942dc00ecadb07b5
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080866

연결된 노트

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