Water → HCID 53927376, 화합물

HRID 1422221노트

반응식

HRID 1422221 반응식
C([O:3][C:4](=[O:24])[CH:5]=[CH:6][C:7](=[O:23])[NH:8][CH2:9][C:10]1[CH:19]=[C:18]([Br:20])[CH:17]=[C:16]2[C:11]=1[NH:12][C:13](=[O:22])[C:14](=[O:21])[NH:15]2)C.O.[OH-].[Li+].O>O1CCCC1.O>[Br:20][C:18]1[CH:17]=[C:16]2[C:11]([NH:12][C:13](=[O:22])[C:14](=[O:21])[NH:15]2)=[C:10]([CH2:9][NH:8][C:7]([CH:6]=[CH:5][C:4]([OH:24])=[O:3])=[O:23])[CH:19]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 54239092HCID 54239092, 화합물

생성물 1

HCID 53927376HCID 53927376, 화합물

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

144 mg (0.36 mmol) of 3-[(7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-carbamoyl]-acrylic acid ethyl ester (Example 10) and 76 mg of lithium hydroxide hydrate are dissolved in 18 ml of tetrahydrofuran/water (2:1) and the solution is stirred for 18 hours. 50 ml of water are added, the tetrahydrofuran is concentrated by evaporation and the solution is acidified with 1 N hydrochloric acid. The solid is filtered off, washed with water and dried.

후처리

  1. concentrationthe tetrahydrofuran is concentrated by evaporation
  2. filtrationThe solid is filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-e0eb2b2da8ec42e688511afacfd80e93
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080743

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