Lithium hydroxide, monohydrate → HCID 18706397, 화합물

HRID 1422225노트

반응식

HRID 1422225 반응식
C([O:3][C:4](=[O:21])[C:5]([S:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[NH:11][C:12](=[O:20])[CH2:13][NH:14]2)=[O:6])C.O.[OH-].[Li+]>O1CCCC1.O>[Br:19][C:17]1[CH:16]=[C:15]2[C:10]([NH:11][C:12](=[O:20])[CH2:13][NH:14]2)=[C:9]([CH2:8][S:7][C:5](=[O:6])[C:4]([OH:21])=[O:3])[CH:18]=1

참가 물질

5

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 86755474HCID 86755474, 화합물

생성물 1

HCID 18706397HCID 18706397, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
20 °C

실험 절차

500 mg (1.34 mmol) of 7-bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethylsulfanylacetic acid ethyl ester (Example 18) are suspended in 20 ml of tetrahydrofuran and 10 ml of water, and 225 mg (4 equiv.) of lithium hydroxide hydrate are added. The mixture is stirred at 20° C. for 48 hours. The tetrahydrofuran is concentrated by evaporation, 60 ml of water are added and the solution is acidified with 1 N hydrochloric acid. The solid is filtered off, washed with water and dried.

후처리

  1. concentrationThe tetrahydrofuran is concentrated by evaporation, 60 ml of water
  2. additionare added
  3. filtrationThe solid is filtered off
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-47cfb5837d8d4fdb906f857fea5a6755
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080743

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