N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-oxalamic acid ethyl ester → N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-oxalamic acid ethyl ester

HRID 1422226노트

반응식

HRID 1422226 반응식
[CH2:1]([O:3][C:4](=[O:24])[C:5]([NH:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[N:11]=[C:12]([O:22]C)[C:13]([O:20]C)=[N:14]2)=[O:6])[CH3:2]>Br.C(O)(=O)C.C(OCC)C>[CH2:1]([O:3][C:4](=[O:24])[C:5]([NH:7][CH2:8][C:9]1[CH:18]=[C:17]([Br:19])[CH:16]=[C:15]2[C:10]=1[NH:11][C:12](=[O:22])[C:13](=[O:20])[NH:14]2)=[O:6])[CH3:2]

참가 물질

5

반응물 1

HCID 54297612N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-oxalamic acid ethyl ester

생성물 1

HCID 54187739N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-ylmethyl)-oxalamic acid ethyl ester

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매HCID 3283Diethyl Ether용매

실험 절차

254 mg (0.79 mmol) of N-(7-bromo-2,3-dimethoxy-quinoxalin-5-ylmethyl)-oxalamic acid ethyl ester are dissolved in 6 ml of an approximately 25% solution of hydrogen bromide in acetic acid, and the solution is stirred at room temperature for 16 hours. The mixture is diluted with diethyl ether, and the solid is filtered off and washed with diethyl ether. After drying under a high vacuum, the title compound is obtained in the form of a beige solid.

후처리

  1. filtrationthe solid is filtered off
  2. washwashed with diethyl ether
  3. customAfter drying under a high vacuum

출처 및 근거

ORD 기록
ord-26280e28dc9f4fdab09f13129e2a8242
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080743

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