Acetic Anhydride → N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-acetamide

HRID 1422232노트

반응식

HRID 1422232 반응식
[NH2:1][CH2:2][C:3]1[CH:12]=[C:11]([N+:13]([O-:15])=[O:14])[CH:10]=[C:9]2[C:4]=1[N:5]=[C:6]([O:18][CH3:19])[C:7]([O:16][CH3:17])=[N:8]2.BrCC1C=C([N+]([O-])=O)C=C2C=1N=[C:25](OC)[C:26]([O:35]C)=N2.C(OC(=O)C)(=O)C.C(N(CC)CC)C>C(N(CC)C=O)C.C(OCC)C>[CH3:17][O:16][C:7]1[C:6]([O:18][CH3:19])=[N:5][C:4]2[C:9](=[CH:10][C:11]([N+:13]([O-:15])=[O:14])=[CH:12][C:3]=2[CH2:2][NH:1][C:26](=[O:35])[CH3:25])[N:8]=1

참가 물질

7

반응물 4

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 179152965-Aminomethyl-2,3-dimethoxy-7-nitro-quinoxalineHCID 232979835-Bromomethyl-7-nitro-2,3-dimethoxyquinoxaline

생성물 1

HCID 18706427N-(2,3-Dimethoxy-7-nitro-quinoxalin-5-ylmethyl)-acetamide

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 12051Diethylformamide용매

실험 절차

111 mg (0.437 mmol) of 5-aminomethyl-2,3-dimethoxy-7-nitro-quinoxaline, obtainable in a manner analogous to that described in Example 9 but starting from 5-bromomethyl-2,3-dimethoxy-7-nitro-quinoxaline, are stirred with 0.046 ml (1.1 equiv.) of acetic anhydride and 0.073 ml (1.2 equiv.) of triethylamine in 5 ml of N,N-diethylformamide at room temperature for 24 hours. The reaction mixture is diluted with diethyl ether, and the solid is filtered off, washed with diethyl ether and dried.

후처리

  1. filtrationthe solid is filtered off
  2. washwashed with diethyl ether
  3. customdried

출처 및 근거

ORD 기록
ord-390f1566680049a9818d0fcf93d57184
출처 데이터셋
uspto-grants-2000_06
특허 번호
US06080743

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