Sodium Hydroxide → 6-Methoxy-[1,5]naphthyridine-3-carboxylic acid
반응식
C([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[N:13][C:12]([O:16][CH3:17])=[CH:11][CH:10]=2)=[O:5])C.[OH-].[Na+]>C(O)C>[CH3:17][O:16][C:12]1[N:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:4]([OH:5])=[O:3])=[CH:15]2참가 물질
4
실험 절차
A mixture of 6-methoxy-[1,5]naphthyridine-3-carboxylic acid ethyl ester (32.0 g, 74.45 mmol, 1.0 eq) and sodium hydroxide (10.12 g, 137.51 mmol, 1.85 eq) in ethanol (110 mL) is refluxed for 3 hours. The solvent is evaporated and the residue is dissolved in water, washed with ethyl acetate, then acidified with 3N hydrochloric acid aqueous solution to pH=3-4. The precipitate is collected by filtration, dried under 50° C. overnight to afford 6-methoxy-[1,5]naphthyridine-3-carboxylic acid as a white solid (24.5 g, 82% yield).
후처리
- temperatureis refluxed for 3 hours
- customThe solvent is evaporated
- dissolutionthe residue is dissolved in water
- washwashed with ethyl acetate
- filtrationThe precipitate is collected by filtration
- customdried under 50° C. overnight
출처 및 근거
- ORD 기록
- ord-629103996e8a4193977bf5fa3746922c
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08927542B2
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