Water → (S)-6-Oxo-piperidine-2-carboxylic acid ((S)-6-mercapto-1-phenylcarbamoyl-hexyl)amide

HRID 1422881노트

반응식

HRID 1422881 반응식
[OH-].[Na+].[O:3]=[C:4]1[NH:9][C@H:8]([C:10]([NH:12][C@H:13]([C:23](=[O:31])[NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][S:19]C(=O)C)=[O:11])[CH2:7][CH2:6][CH2:5]1.O>CCO>[SH:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]([NH:12][C:10]([C@@H:8]1[CH2:7][CH2:6][CH2:5][C:4](=[O:3])[NH:9]1)=[O:11])[C:23](=[O:31])[NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 71506894HCID 71506894, 화합물

생성물 1

HCID 71538746(S)-6-Oxo-piperidine-2-carboxylic acid ((S)-6-mercapto-1-phenylcarbamoyl-hexyl)amide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A 2N solution of NaOH (7.0 mmol) was added to a solution of thioacetic acid S—{(S)-6-[((S)-6-oxo-piperidine-2-carbonyl)-amino]-6-phenylcarbamoyl-hexyl}ester (0.95 mmol) in EtOH (13 ml). The reaction mixture was stirred at RT overnight and then poured into water and extracted with AcOEt, washed with water, brine and finally dried over Na2SO4. Removal of the solvent under reduced pressure led to the desired adduct, which was purified through HPLC.

후처리

  1. extractionextracted with AcOEt
  2. washwashed with water, brine
  3. dry with materialfinally dried over Na2SO4
  4. customRemoval of the solvent under reduced pressure
  5. customwas purified through HPLC

출처 및 근거

ORD 기록
ord-d7ce9162b904417ea3458f4e33a379d9
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927533B2

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