Phthalic Anhydride → HCID 178487812, 화합물
반응식
[C:1]1(=[O:11])[O:6][C:4](=O)[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH3:12][O:13][C:14]1[N:15]=[C:16]2[C:25](=[CH:26][CH:27]=1)[N:24]=[CH:23][C:22]1[O:21][CH2:20][CH:19]([C@H:28]3[CH2:33][CH2:32][C@H:31]([NH2:34])[CH2:30][CH2:29]3)[NH:18][C:17]2=1>N1C=CC=CC=1>[CH3:12][O:13][C:14]1[N:15]=[C:16]2[C:25](=[CH:26][CH:27]=1)[N:24]=[CH:23][C:22]1[O:21][CH2:20][CH:19]([C@H:28]3[CH2:33][CH2:32][C@H:31]([N:34]4[C:1](=[O:11])[C:2]5[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=5)[C:4]4=[O:6])[CH2:30][CH2:29]3)[NH:18][C:17]2=1참가 물질
4
실험 절차
Phthalic anhydride (200 mg, 1.34 mmol, 2.53 eq) is added at room temperature to a stirred solution of trans-4-(6-methoxy-3,4-dihydro-2H-1-oxa-4,5,9-triaza-phenanthren-3-yl)-cyclohexylamine (200 mg, 0.53 mmol, 1.0 eq) in pyridine (4 mL). The reaction mixture is heated to reflux for 3 hours, pyridine is then removed and acetic anhydride (1 mL) is added. The resulting mixture is heated to reflux for 2 hours, then extracted with ethyl acetate (3×10 mL) and water (5 mL). The combined organic layers are dried over sodium sulfate, filtered and concentrated to afford 2-[trans-4-(6-methoxy-3,4-dihydro-2H-1-oxa-4,5,9-triaza-phenanthren-3-yl)-cyclohexyl]-isoindole-1,3-dione as a light brown semisolid (190 mg, 69% yield).