Water → 8-Bromo-3-(4-fluorophenyl)-imidazo[1,5-a]pyridine
반응식
[Br:1][C:2]1[C:3]([CH2:8][NH:9][C:10](=O)[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.O.C(=O)([O-])[O-].[K+].[K+]>O=P(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]2[N:4]([C:10]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)=[N:9][CH:8]=2)[CH:5]=[CH:6][CH:7]=1참가 물질
5
실험 절차
A mixture of N-(3-bromopyridin-2-ylmethyl)-4-fluoro-benzamide (594 mg, 1.92 mmol) in POCl3 (5.0 mL) is warmed at reflux. After 1.5 hours, the mixture is cooled to room temperature and poured into water while adding crushed ice to control the exotherm. The mixture is made basic with potassium carbonate and the precipitate is collected by filtration to afford 8-bromo-3-(4-fluorophenyl)-imidazo[1,5-a]pyridine.
후처리
- temperatureis warmed
- temperatureat reflux
- additionwhile adding
- customcrushed ice
- filtrationthe precipitate is collected by filtration
출처 및 근거
- ORD 기록
- ord-8eca7b9c1663474aa8ed7425d631c30f
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08927550B2
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