Hydrochloric Acid → (S)-1-(2-methanesulfonyl-thiazol-5-yl)-propylamine hydrochloride

HRID 1423043노트

반응식

HRID 1423043 반응식
[CH3:1][S:2]([C:5]1[S:6][C:7]([C@@H:10]([NH:13]S(C(C)(C)C)=O)[CH2:11][CH3:12])=[CH:8][N:9]=1)(=[O:4])=[O:3].[ClH:20]>CO.O1CCOCC1>[ClH:20].[CH3:1][S:2]([C:5]1[S:6][C:7]([C@@H:10]([NH2:13])[CH2:11][CH3:12])=[CH:8][N:9]=1)(=[O:3])=[O:4]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 667274522-methyl-propane-2-sulfinic acid [(S)-1-(2-methanesulfonyl-thiazol-5-yl)-propyl]amide

생성물 1

HCID 66727345(S)-1-(2-methanesulfonyl-thiazol-5-yl)-propylamine hydrochloride

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(2-methanesulfonyl-thiazol-5-yl)-propyl]-amide (80 mg, 0.3 mmol) in methanol (5 mL) is added a 4 N solution of hydrochloric acid (1 mL, 4 mmol) in dioxane. After 1 hour, the mixture is concentrated and diluted with dichloromethane (2 mL) followed by hexanes (10 mL), and concentrated to afford (S)-1-(2-methanesulfonyl-thiazol-5-yl)-propylamine hydrochloride.

후처리

  1. concentrationthe mixture is concentrated
  2. additiondiluted with dichloromethane (2 mL)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fdb5b819a3984390a494bce9683d5af0
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927550B2

반응 노트

불러오는 중…