isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxy-benzoate → 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acid

HRID 1423337노트

반응식

HRID 1423337 반응식
[CH:1]1([C:4]2[N:5]=[CH:6][N:7]([C:9]3[CH:10]=[CH:11][C:12]([O:21][CH3:22])=[C:13]([CH:20]=3)[C:14]([O:16]C(C)C)=[O:15])[CH:8]=2)[CH2:3][CH2:2]1>Cl>[CH:1]1([C:4]2[N:5]=[CH:6][N:7]([C:9]3[CH:10]=[CH:11][C:12]([O:21][CH3:22])=[C:13]([CH:20]=3)[C:14]([OH:16])=[O:15])[CH:8]=2)[CH2:2][CH2:3]1

참가 물질

3

반응물 1

HCID 58035659isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxy-benzoate

생성물 1

HCID 580356325-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acid수율 100%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoate (0.720 g, 2.4 mmol) in 2N hydrochloric acid (10 ml) was heated to 100° C. for 10 hours. The solvent was removed under reduced pressure to give 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acid (HCl salt) as a brown powder. (0.715 g, 2.4 mmol). 100% yield. 259 (M+1).

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-7ea49d58377e4ea68d6a375368dbe1ff
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927582B2

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