Hydrochloric Acid → Methyl (4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]-L-prolinate hydrochloride

HRID 1423375노트

반응식

HRID 1423375 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:14][C@H:15]3[CH2:19][N:18](C(OC(C)(C)C)=O)[C@H:17]([C:27]([O:29][CH3:30])=[O:28])[CH2:16]3)=[CH:8][C:9](=[O:13])[NH:10]2)=[CH:5][C:4]=1[CH:31]=[CH2:32].[ClH:33]>>[ClH:33].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([O:14][C@H:15]3[CH2:19][NH:18][C@H:17]([C:27]([O:29][CH3:30])=[O:28])[CH2:16]3)=[CH:8][C:9](=[O:13])[NH:10]2)=[CH:5][C:4]=1[CH:31]=[CH2:32]

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 592799081-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate

생성물 1

HCID 86643488Methyl (4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]-L-prolinate hydrochloride

실험 절차

To the product from Step 3, 1-tert-butyl 2-methyl (2S,4R)-4-[(7-methoxy-2-oxo-6-vinyl-1,2-dihydroquinolin-4-yl)oxy]pyrrolidine-1,2-dicarboxylate (2.02 g, 4.54 mmol) was added HCl (4M in dioxane) (22.72 ml, 91 mmol) at r.t. After 1.5 h, the solvent was removed in vacuo. The residue was taken up in Et2O and the solvent was removed in vacuo to yield 1.73 (99%) g of the title compound as a tan solid. LRMS ESI+ (M+H)+ 345.4.

후처리

  1. customthe solvent was removed in vacuo
  2. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-042f8635dd4549ccb633492c865ba8a6
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927569B2

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