Methyl 3-oxovalerate → Methyl (2Z)-3-amino-2-pentenoate

HRID 1424388노트

반응식

HRID 1424388 반응식
O=[C:2]([CH2:8][CH3:9])[CH2:3][C:4]([O:6][CH3:7])=[O:5].C([O-])(=O)C.[NH4+:14]>CO>[NH2:14]/[C:2](/[CH2:8][CH3:9])=[CH:3]\[C:4]([O:6][CH3:7])=[O:5]

참가 물질

4

반응물 2

HCID 121699Methyl 3-oxovalerateHCID 517165Ammonium Acetate

생성물 1

HCID 21343688Methyl (2Z)-3-amino-2-pentenoate수율 18,415.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of methyl 3-oxovalerate (75.0 g, 576 mmol), ammonium acetate (222 g, 2.88 mmol) and methanol (750 mL) was stirred at room temperature for 3 days. After concentration under reduced pressure, and water (500 mL) was added to the residue and the mixture was extracted with ethyl acetate (200 mL). The extract was washed with brine, dried over magnesium sulfate, concentrated under reduced pressure, and dried to give the title compound (68.5 g, 92%) as a pale-yellow oil.

후처리

  1. concentrationAfter concentration under reduced pressure, and water (500 mL)
  2. additionwas added to the residue
  3. extractionthe mixture was extracted with ethyl acetate (200 mL)
  4. washThe extract was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customdried

출처 및 근거

ORD 기록
ord-6f9df84874a24bc683b5f9270eb90455
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927718B2

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