Sodium Hydroxide → 5-(4-Cyano-2-fluorophenyl)-1,2-oxazole-3-carboxylic acid
반응식
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][C:12]=2[F:19])[O:8][N:7]=1)=[O:5])C.[OH-].[Na+]>O1CCCC1>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([C:9]2[O:8][N:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=2)=[C:12]([F:19])[CH:13]=1)#[N:18]참가 물질
4
실험 절차
The title compound is prepared from 5-(4-cyano-2-fluoro-phenyl)-isoxazole-3-carboxylic acid ethyl ester by treatment with aqueous NaOH solution in tetrahydrofuran. LC (method 4): tR=0.32 min; Mass spectrum (EI): m/z=232 [M]+.
출처 및 근거
- ORD 기록
- ord-a698dc6f20ce4061be07a7d5a5907e0b
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08927726B2
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