Acetic Anhydride → HCID 64498, 화합물

HRID 1424578노트

반응식

HRID 1424578 반응식
[NH2:1][CH:2]1[CH:9]2[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:11][CH:3]1[CH2:4]3)[CH2:8]2.[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1.CCOC(C)=O>[CH:9]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:11][CH:3]([CH2:4]3)[CH:2]1[NH:1][C:12](=[O:14])[CH3:13])[CH2:8]2

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 253322-Aminoadamantane

생성물 1

HCID 64498HCID 64498, 화합물수율 60%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2-aminoadamantane (20 g, 108 mmol) in dry pyridine (120 mL) was treated with acetic anhydride (12 mL, 128 mmol) and stirred overnight at rt. The mixture was dilute with EtOAc and washed with water, 1 N aq phosphoric acid and brine. The organic layer was dried, filtered and concentrated to give N-(2-adamantyl)acetamide (12.5 g, 60%). 1H NMR (400 MHz, CDCl3): δ=1.57 (m, 2H), 1.67 (m, 3H), 1.72 (m, 1H), 1.77 (m, 6H), 1.85 (m, 2H), 1.94 (s, 3H), 3.97 (t, 1H), 5.78 (br, 1H).

후처리

  1. washwashed with water, 1 N aq phosphoric acid and brine
  2. customThe organic layer was dried
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-281b11ab6ee248f6933c90729793ff7b
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927715B2

반응 노트

불러오는 중…