Ammonium formate → HCID 67548762, 화합물

HRID 1425033노트

반응식

HRID 1425033 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:14]=2)=[CH:6][CH:5]=1)([O-])=O.C([O-])=O.[NH4+]>[Pd].CO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[S:11][C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:13][N:14]=2)=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 53403660Ethyl 2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate

생성물 1

HCID 67548762HCID 67548762, 화합물수율 75%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The same operation as in Example (90d) was performed using ethyl 2-(4-nitrophenyl)-1,3-thiazole-5-carboxylate obtained in Example (91a) (0.18 g, 0.65 mmol), 10% Pd/C (wet, 0.1 g), ammonium formate (0.2 g, 3.24 mmol) and methanol (5 mL), to obtain 0.12 g of the crude title compound as a yellow solid (75%).

출처 및 근거

ORD 기록
ord-db93412fd98f432ba9775bef29310d21
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927588B2

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