Triethyl phosphite → HCID 71059611, 화합물

HRID 1425598노트

반응식

P(OCC)(OCC)OCC.[CH2:11]([O:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[N+:31]([O-])=O)=[N:23][CH:24]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:11]([O:18][C:19]1[CH:24]=[N:23][C:22]2[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[NH:31][C:21]=2[CH:20]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 31215Triethyl phosphite

HCID 71059520HCID 71059520, 화합물

생성물 1

HCID 71059611HCID 71059611, 화합물수율 33.5%

실험 절차

Triethyl phosphite (3 ml, 17.15 mmol) and 5-(benzyloxy)-2-(2-nitrophenyl)pyridine (0.3 g, 0.979 mmol) were heated to 125° C. for 4 hours. Let the reaction cool to room temperature. Concentrated and purified with Combiflash column using ethyl acetate followed by 15% methanol in DCM to afford 3-(benzyloxy)-5H-pyrido[3,2-b]indole (0.09 g, 0.328 mmol, 33.5% yield).

후처리

concentrationConcentrated
custompurified with Combiflash column

출처 및 근거

ORD 기록: ord-ab52351d8f5c44ec8589fcb2655728da
출처 데이터셋: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08932557B2

반응 노트

불러오는 중…