Sulfuric Acid → HCID 67996687, 화합물

HRID 1425955노트

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HRID 1425955 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)=[N:6][CH:7]=1.S(=O)(=O)(O)[OH:14].[OH-].[Na+]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:11]([NH2:12])=[O:14])[CH2:9][CH2:10]2)=[N:6][CH:7]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 534029901-(5-Bromopyridin-2-yl)cyclopropane-1-carbonitrile

생성물 1

HCID 67996687HCID 67996687, 화합물

실험 절차

A mixture of 1-(5-bromo-pyridin-2-yl)-cyclopropanecarbonitrile (0.18 g) and sulfuric acid (95%, 1.8 mL) was stirred at room temperature overnight. The solution was poured on crushed ice and the resulting solution was basified using 4 M aqueous NaOH solution. The solution was extracted with dichloromethane, the combined extracts were dried (Na2SO4), and the solvent was evaporated to give the title compound as a colorless solid. Yield: 0.20 g (quantitative); LC (method 2): tR=2.38 min; Mass spectrum (ESI+): m/z=241/243 (Br) [M+H]+.

후처리

  1. additionThe solution was poured
  2. customon crushed ice
  3. extractionThe solution was extracted with dichloromethane
  4. dry with materialthe combined extracts were dried (Na2SO4)
  5. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-a268be6ce24a4d61a7c48ab513658c7d
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933072B2

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