Hydrochloric Acid → (R)-N-(3-chloropropyl)-5-(2-(5-fluoro-2-oxo-1,2-dihydropyridin-3-yl)pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide

HRID 1426933노트

반응식

HRID 1426933 반응식
Cl.[Cl:2][CH2:3][CH2:4][CH2:5][N:6]([CH3:32])[C:7]([C:9]1[CH:10]=[N:11][N:12]2[CH:17]=[CH:16][C:15]([N:18]3[CH2:22][CH2:21][CH2:20][C@@H:19]3[C:23]3[C:24]([O:30]C)=[N:25][CH:26]=[C:27]([F:29])[CH:28]=3)=[N:14][C:13]=12)=[O:8]>C(#N)C>[Cl:2][CH2:3][CH2:4][CH2:5][N:6]([CH3:32])[C:7]([C:9]1[CH:10]=[N:11][N:12]2[CH:17]=[CH:16][C:15]([N:18]3[CH2:22][CH2:21][CH2:20][C@@H:19]3[C:23]3[C:24](=[O:30])[NH:25][CH:26]=[C:27]([F:29])[CH:28]=3)=[N:14][C:13]=12)=[O:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67470673(R)-N-(3-chloropropyl)-5-(2-(5-fluoro-2-methoxypyridin-3-yl)pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide

생성물 1

HCID 67470639(R)-N-(3-chloropropyl)-5-(2-(5-fluoro-2-oxo-1,2-dihydropyridin-3-yl)pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide수율 150%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
90 °C

실험 절차

A mixture of HCl (4 N dioxane, 4 mL, 16.0 mmol) and (R)-N-(3-chloropropyl)-5-(2-(5-fluoro-2-methoxypyridin-3-yl)pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide (100 mg, 0.224 mmol) was sealed in a pressure tube and heated at 90° C. for 90 minutes. The reaction mixture was then diluted with acetonitrile and concentrated to yield the crude product, which was carried to the next step without further purification (145 mg, 150% yield). MS (apci) m/z=433.0 (M+H).

후처리

  1. customwas sealed in a pressure tube
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-31017785c4ea47febdb8ff02f667690d
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933084B2

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