Sodium Hydroxide → 4-Butyrylbenzoic acid

HRID 1427521노트

반응식

HRID 1427521 반응식
[C:1]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([O:12]C)=[O:11])=[CH:8][CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>O1CCCC1.CO>[C:1]([C:6]1[CH:15]=[CH:14][C:9]([C:10]([OH:12])=[O:11])=[CH:8][CH:7]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 23143286Methyl 4-butyrylbenzoate

생성물 1

HCID 189835644-Butyrylbenzoic acid수율 65.1%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

Methyl 4-butyrylbenzoate (256.1 mg, 1.242 mmol) was dissolved in tetrahydrofuran (3 mL) and methanol (3.0 mL). 1N aqueous sodium hydroxide (3.73 mL) was added and the reaction mixture was heated to 50° C. for 3 h. The reaction mixture was then cooled to room temperature and concentrated. The crude residue was taken up in water and acidified to pH 5 by addition of 1N aqueous HCl. A colorless precipitate formed. The solids were filtered off and dried under vacuum to give 4-butyrylbenzoic acid (155.4 mg, 65%) as a colorless solid.

후처리

  1. temperatureThe reaction mixture was then cooled to room temperature
  2. concentrationconcentrated
  3. additionacidified to pH 5 by addition of 1N aqueous HCl
  4. customA colorless precipitate formed
  5. filtrationThe solids were filtered off
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-51c475b6862948a1b4dd431105a01192
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933104B2

반응 노트

불러오는 중…