Water → 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

HRID 1428123노트

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HRID 1428123 반응식
[Br:1]N1C(=O)CCC1=O.[CH3:9][C:10]1([CH3:24])[C:14]([CH3:16])([CH3:15])[O:13][B:12]([C:17]2[C:18]([NH2:23])=[N:19][CH:20]=[CH:21][CH:22]=2)[O:11]1.O>CN(C=O)C>[Br:1][C:21]1[CH:22]=[C:17]([B:12]2[O:11][C:10]([CH3:24])([CH3:9])[C:14]([CH3:15])([CH3:16])[O:13]2)[C:18]([NH2:23])=[N:19][CH:20]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 438110672-Aminopyridine-3-boronic acid, pinacol ester

생성물 1

HCID 867000765-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine수율 51.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

N-Bromosuccinimide (255 mg) was added to a solution of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (300 mg) in DMF (6.8 ml) at room temperature, and the mixture was stirred for four hours. Water was added and the precipitated solid was collected by filtration to give 210 mg of the title compound.

후처리

  1. filtrationthe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-4657539fb2ef4a72a457d2c930710a26
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933103B2

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