n-Butyl(S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylate → (S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylic acid

HRID 1428205노트

반응식

HRID 1428205 반응식
[O:1]=[C:2]1[NH:7][N:6]=[CH:5][C:4]([C:8]([NH:10][C@@:11]2([C:16]([O:18]CCCC)=[O:17])[CH2:15][CH2:14][O:13][CH2:12]2)=[O:9])=[CH:3]1>[OH-].[Na+]>[O:1]=[C:2]1[NH:7][N:6]=[CH:5][C:4]([C:8]([NH:10][C@@:11]2([C:16]([OH:18])=[O:17])[CH2:15][CH2:14][O:13][CH2:12]2)=[O:9])=[CH:3]1

참가 물질

3

반응물 1

HCID 68023757n-Butyl(S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylate

생성물 1

HCID 59496525(S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylic acid수율 71%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

n-Butyl(S)-3-[(6-oxo-1,6-dihydro-pyridazine-4-carbonyl)-amino]-tetrahydrofuran-3-carboxylate (21.0 g, 67.9 mmol) was stirred vigorously in 200 mL of 1N sodium hydroxide solution for 1 hour. The mixture was then extracted twice with 100 mL of diethyl ether, the alkaline aqueous phase was then combined with 50 mL of 4N hydrochloric acid. The mixture was then evaporated to dryness and the residue was stirred with 150 mL ethanol. Undissolved ingredients were then filtered off and the filtrate was evaporated down. In this way the product was obtained in a yield of 71% of theory. The product thus obtained was further processed without purification.

후처리

  1. extractionThe mixture was then extracted twice with 100 mL of diethyl ether
  2. customThe mixture was then evaporated to dryness
  3. filtrationwere then filtered off
  4. customthe filtrate was evaporated down
  5. customIn this way the product was obtained in a yield of 71% of theory
  6. customThe product thus obtained
  7. customwas further processed without purification

출처 및 근거

ORD 기록
ord-9832b58a18594b9a85fca5add5a83dab
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937073B2

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