Ammonia → (4-Aminomethyl-phenyl)-(4-methoxy-2-trifluoromethyl-phenyl)-amine
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][CH:11]=2)=[C:5]([C:18]([F:21])([F:20])[F:19])[CH:4]=1.N>CO.[Ni]>[NH2:15][CH2:14][C:13]1[CH:12]=[CH:11][C:10]([NH:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=2[C:18]([F:19])([F:20])[F:21])=[CH:17][CH:16]=1참가 물질
5
실험 절차
3.7 g (12.7 mmol) of 4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile were hydrogenated in a 7N solution of ammonia in methanol (100 mL) with the addition of Raney nickel at ambient temperature. After the catalyst had been filtered off and the solvent distilled off, the crude product thus obtained was reacted further without purification.
후처리
- filtrationAfter the catalyst had been filtered off
- distillationthe solvent distilled off
출처 및 근거
- ORD 기록
- ord-ba359a48b5cd4297b44ae174ad0da289
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08937073B2
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