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Hydrochloric Acid → (S)-5-amino-N-(3-{[5-(4-methoxy-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamoyl}-tetrahydrofuran-3-yl)-nicotinamide

HRID 1428221
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HRID 1428221 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:16][NH:17][C:18]([C@:20]3([NH:25][C:26]([C:28]4[CH:29]=[C:30]([NH:34]C(=O)OC(C)(C)C)[CH:31]=[N:32][CH:33]=4)=[O:27])[CH2:24][CH2:23][O:22][CH2:21]3)=[O:19])=[N:14][CH:15]=2)=[C:5]([C:42]([F:45])([F:44])[F:43])[CH:4]=1.Cl>O1CCOCC1>[NH2:34][C:30]1[CH:31]=[N:32][CH:33]=[C:28]([CH:29]=1)[C:26]([NH:25][C@@:20]1([C:18](=[O:19])[NH:17][CH2:16][C:13]2[CH:12]=[CH:11][C:10]([NH:9][C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=3[C:42]([F:44])([F:45])[F:43])=[CH:15][N:14]=2)[CH2:24][CH2:23][O:22][CH2:21]1)=[O:27]
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참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68026201tert-Butyl(S)-[5-(3-{[5-(4-methoxy-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamoyl}-tetrahydrofuran-3-ylcarbamoyl)-pyridin-3-yl]-carbamate

생성물 1

HCID 56840394(S)-5-amino-N-(3-{[5-(4-methoxy-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamoyl}-tetrahydrofuran-3-yl)-nicotinamide

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

tert-Butyl(S)-[5-(3-{[5-(4-methoxy-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamoyl}-tetrahydrofuran-3-ylcarbamoyl)-pyridin-3-yl]-carbamate (product from Example 5e, 1.2 mmol) was stirred with a 4N HCl solution in dioxane (20 mL) for two hours at ambient temperature. Then the mixture was evaporated to dryness, the residue was triturated with approx. 20 mL diethyl ether and suction filtered.

후처리

  1. customThen the mixture was evaporated to dryness
  2. customthe residue was triturated with approx. 20 mL diethyl ether and suction
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-c99dd9d2a29e46d399066bab0246ed24
출처 데이터셋
uspto-grants-2015_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08937073B2

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