Ammonium Acetate → HCID 86688149, 화합물

HRID 1428944노트

반응식

HRID 1428944 반응식
[CH2:1]([O:8][CH2:9][C:10]([N:12]([CH2:24][CH3:25])[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][C:19]([F:22])=[C:18]([CH3:23])[CH:17]=1)=O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])(=O)C.[NH4+:30]>ClCCl>[CH2:1]([O:8][CH2:9][C:10]1[N:12]([CH2:24][CH3:25])[CH:13]=[C:14]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[C:18]([CH3:23])[CH:17]=2)[N:30]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 517165Ammonium AcetateHCID 86688147HCID 86688147, 화합물

생성물 1

HCID 86688149HCID 86688149, 화합물수율 74.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5.8 g 2-benzyloxy-N-ethyl-N-[2-(4-fluoro-3-methyl-phenyl)-2-oxo-ethyl]-acetamide and 4 g ammonium acetate was melted at 200° C. for 30 min Dichlormethane was added and the mixture was washed with aqueous potassiumhydrogen carbonate solution. The organic layer was evaporated. The residue was purified by chromatographie on silica gel (cyclohexane/ethyl acetate 4:1) to yield 4.1 g of the desired product. Rt: 0.74 min (method J), (M+H)+: 325

후처리

  1. customfor 30 min
  2. additionwas added
  3. washthe mixture was washed with aqueous potassiumhydrogen carbonate solution
  4. customThe organic layer was evaporated
  5. customThe residue was purified by chromatographie on silica gel (cyclohexane/ethyl acetate 4:1)

출처 및 근거

ORD 기록
ord-8daea9d4e22d48eb8921d82f9d79a469
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937176B2

반응 노트

불러오는 중…