2-Methoxybenzenesulfonyl Chloride → 4-(4-Bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahydro-1H-benzo-[f][1,4]oxazocine

HRID 1429367노트

반응식

HRID 1429367 반응식
[Br:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][CH:7]2[NH:14][CH2:13][C:12]3[CH:15]=[CH:16][CH:17]=[CH:18][C:11]=3[CH2:10][O:9][CH2:8]2)=[CH:4][CH:3]=1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[S:29](Cl)(=[O:31])=[O:30]>C(#N)C.CN(C1C=CN=CC=1)C>[Br:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][CH:7]2[N:14]([S:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[O:22][CH3:21])(=[O:31])=[O:30])[CH2:13][C:12]3[CH:15]=[CH:16][CH:17]=[CH:18][C:11]=3[CH2:10][O:9][CH2:8]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 37458512-Methoxybenzenesulfonyl ChlorideHCID 674173634(4-Bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

생성물 1

HCID 674165884-(4-Bromobenzyl)-5-((2-methoxyphenyl)sulfonyl)-3,4,5,6-tetrahydro-1H-benzo-[f][1,4]oxazocine수율 38%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6342Acetonitrile용매

실험 절차

To a mixture of compound 3l (900 mg, 2.7 mmol) and TEA (546 mg, 5.4 mmol) in acetonitrile (30 mL) was added 2-methoxybenzene sulfonyl chloride (559 mg, 2.7 mmol) and catalytic amount of DMAP. The reaction mixture was stirred at rt overnight. The solvent was evaporated in vacuo and purified by CC to give 3 as a white solid (510 mg, 38% yield).

후처리

  1. customThe solvent was evaporated in vacuo
  2. custompurified by CC

출처 및 근거

ORD 기록
ord-b1e313ab658c485890c85a8ff3cdb601
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940722B2

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