Acetic Acid → HCID 59805850, 화합물

HRID 1429659노트

반응식

HRID 1429659 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH:5]=O.[CH2:11]1[CH2:20][O:19][C:13]2([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[O:12]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(O)(=O)C>ClC(Cl)C>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5][N:16]1[CH2:17][CH2:18][C:13]2([O:19][CH2:20][CH2:11][O:12]2)[CH2:14][CH2:15]1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 5880883,4-DifluorobenzaldehydeHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 59805850HCID 59805850, 화합물수율 98%

시약·촉매·용매 1

HCID 63651,1-Dichloroethane용매

실험 절차

A solution of 3,4-difluorobenzaldehyde (4.40 g, 30.9 mmol), 4,4-ethylenedioxy-piperidine (4.40 g, 30.9 mmol), sodium triacetoxyborohydride (6.40 g, 30.2 mmol) and acetic acid (1.8 g, 30.0 mmol) in dichloroethane (200 ml) was stirred at room temperature for 18 h. After this period, the reaction mixture was washed with 1N sodium hydroxide. The organic layer separated, dried (MgSO4) and the solvents evaporated in vacuo to give D3 (7.9 g, 98%). C14H17F2NO2 requires 269; Found 270 (MH+)

후처리

  1. waitAfter this period
  2. washthe reaction mixture was washed with 1N sodium hydroxide
  3. customThe organic layer separated
  4. dry with materialdried (MgSO4)
  5. customthe solvents evaporated in vacuo

출처 및 근거

ORD 기록
ord-973d092066be432e8254e4b43c05a749
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940743B2

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