HCID 59805850, 화합물 → HCID 23218604, 화합물

HRID 1429660노트

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HRID 1429660 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]1[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8][CH2:7]1>Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][C:18]=1[F:19])[CH2:5][N:6]1[CH2:7][CH2:8][C:9](=[O:10])[CH2:14][CH2:15]1

참가 물질

3

반응물 1

HCID 59805850HCID 59805850, 화합물

생성물 1

HCID 23218604HCID 23218604, 화합물수율 82%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of D3 (7.9 g, 29.4 mmol) in hydrochloric acid (5N, 150 ml) was heated at 50° C. for 2 h. After this period, the reaction mixture was washed with diisopropyl ether (100 ml) and then a saturated solution of sodium hydrogen carbonate (100 ml). The mixture was then extracted with dichloromethane and the extracts dried (MgSO4) and the solvents evaporated in vacuo to give D4 (5.4 g, 82%). C12H13F2NO requires 225; Found 226 (MH+)

후처리

  1. waitAfter this period
  2. washthe reaction mixture was washed with diisopropyl ether (100 ml)
  3. extractionThe mixture was then extracted with dichloromethane
  4. dry with materialthe extracts dried (MgSO4)
  5. customthe solvents evaporated in vacuo

출처 및 근거

ORD 기록
ord-ccfb022391a645d6a65c2d2295802ece
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940743B2

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