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Diisopropylethylamine → HCID 178463611, 화합물

HRID 1429818
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HRID 1429818 반응식
[NH2:1][CH:2]([C:4]1[N:5]=[C:6]2[S:21][CH:20]=[CH:19][N:7]2[C:8](=[O:18])[C:9]=1[C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=1)[CH3:3].[NH2:22][C:23]1[N:31]=[C:30]2[C:26]([NH:27][CH:28]=[N:29]2)=[C:25](Br)[N:24]=1.C(N(CC)C(C)C)(C)C>C(O)C>[NH2:22][C:23]1[N:31]=[C:30]2[C:26]([N:27]=[CH:28][NH:29]2)=[C:25]([NH:1][CH:2]([C:4]2[N:5]=[C:6]3[S:21][CH:20]=[CH:19][N:7]3[C:8](=[O:18])[C:9]=2[C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=2)[CH3:3])[N:24]=1
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참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 61011392-Amino-6-bromopurineHCID 581114057-(1-aminoethyl)-6-(3,5-difluorophenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

생성물 1

HCID 178463611HCID 178463611, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
110 °C

실험 절차

A mixture of 7-(1-aminoethyl)-6-(3,5-difluorophenyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one (0.040 g, 0.13 mmol), 2-amino-6-bromopurine (0.056 g, 0.26 mmol), and N,N-diisopropylethylamine (0.045 mL, 0.26 mmol) in ethanol (0.5 mL) was heated at 110° C. overnight. The mixture was filtered, and the filtrate was purified on preparative-LCMS (XBridge C18 Column, eluting with a gradient of acetonitrile/water containing 0.15% NH4OH), to give the desired product. LCMS calculated for C19H15F2N8OS (M+H)+: m/z=441.1. Found: 441.1.

후처리

  1. filtrationThe mixture was filtered
  2. customthe filtrate was purified on preparative-LCMS (XBridge C18 Column
  3. washeluting with a gradient of acetonitrile/water containing 0.15% NH4OH),

출처 및 근거

ORD 기록
ord-77962346181b40468e82cc6d5c12ebf2
출처 데이터셋
uspto-grants-2015_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08940752B2

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