Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 4-Morpholino-2-nitrobenzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 4-Chloro-2-nitrobenzonitrile | HCID 96924 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Morpholino-2-nitrobenzonitrile | HCID 13499265 | — |
반응 단계
To a stirred solution of 4-chloro-2-nitrobenzonitrile (2.0 g, 11 mmol) in THF (40 mL) was added morpholine (1.0 g, 11 mmol). The reaction was heated at reflux overnight. After this time the reaction was cooled to rt and then it was partitioned between EtOAc (150 mL) and NaHCO3 (50 mL, satd aq. solution). The separated organic layer was dried over magnesium sulfate, filtered and evaporated in vacuo. Column chromatography (hexanes:EtOAc, 1:0 to 1:1) gave 4-morpholino-2-nitrobenzonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08940724B2 |
| 출처 데이터셋 | uspto-grants-2015_01 |
| ORD ID | ord-9b10deb16b3e47efb2cf95c1b8f87c24 |
| 출처 메모 | uspto-grants-2015_01 |