2-Cyclohexen-1-one → 1,3-Diethyl 2-(3-oxocyclohexyl)propanedioate

HRID 14322

반응식

HRID 14322 반응식
C1(=O)CCCC=C1.[CH2:8]([O:10][C:11](=[O:28])[CH:12]([CH:18]1[CH2:23][CH2:22][CH:21](CCC)[C:20](=[O:27])[CH2:19]1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH3:9]>>[CH2:16]([O:15][C:13](=[O:14])[CH:12]([CH:18]1[CH2:23][CH2:22][CH2:21][C:20](=[O:27])[CH2:19]1)[C:11]([O:10][CH2:8][CH3:9])=[O:28])[CH3:17]

참가 물질

3

반응물 2

HCID 135942-Cyclohexen-1-oneHCID 574874362-(3-Oxo-4-propylcyclohexyl)-malonic acid diethyl ester

생성물 1

HCID 3170491,3-Diethyl 2-(3-oxocyclohexyl)propanedioate수율 88%

실험 절차

Step 1 (3-Oxo-cyclohexyl)-malonic acid diethyl ester was prepared in 88% yield from cyclohexenone by the method described above for the synthesis of 2-(3-oxo-4-propylcyclohexyl)-malonic acid diethyl ester: 1H NMR (300 MHz, CDCl3) δ 4.44-4.12 (m, 4H), 2.88-1.22 (m, 16H).

출처 및 근거

ORD 기록
ord-c7b90190713c40bf8958b5e59dd4121e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

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